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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
Clonal deletion of autoreactive thymocytes is important for self-tolerance, but the intra-thymic signals that induce clonal deletion have not been clearly identified. We now report that clonal deletion during negative selection requires CD28 costimulation of autoreactive thymocytes at the CD4(+)CD8(...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362677/ https://ncbi.nlm.nih.gov/pubmed/22544394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2292 |
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