Pre-steady state kinetic analysis of cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIV-1 reverse transcriptase

Pre-steady state kinetic analysis was utilized for biochemical evaluation of a series of cyclobutyl adenosine nucleotide analogs with HIV-1 RT(WT). The phosphonyl-diphosphate form of the cyclobutyl nucleotide, 5, was the most efficiently incorporated of the series. Nucleotide 5 was 4-fold more effic...

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Hlavní autoři: Kim, Jiae, Wang, Ligong, Li, Yongfeng, Becnel, Kimberlynne D., Frey, Kathleen M., Garforth, Scott J., Prasad, Vinayaka R., Schinazi, Raymond F., Liotta, Dennis C., Anderson, Karen S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362660/
https://ncbi.nlm.nih.gov/pubmed/22595174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.078
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