Synthesis and Evaluation of 2’-Substituted Cyclobutyl Nucleosides and Nucleotides as Potential Anti-HIV Agents

A series of 2’-substituted cyclobutyl nucleoside analogs were efficiently prepared by constructing the core cyclobutyl ring using different [2+2] cycloaddition approaches. The triphosphate derivative of a cyclobutyl nucleoside was also synthesized and evaluated against wild-type and mutant HIV rever...

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Foilsithe in:Bioorg Med Chem Lett
Main Authors: Li, Yongfeng, Mao, Shuli, Hager, Michael W., Becnel, Kimberlynne D., Schinazi, Raymond F., Liotta, Dennis C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776709/
https://ncbi.nlm.nih.gov/pubmed/17434736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.03.094
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