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An unusual dimeric structure and assembly for RP105–MD-1, a regulator for the TLR4 response to LPS
RP105–MD-1 modulates the TLR4–MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105–MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homologue TLR4–MD-2, but as...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362203/ https://ncbi.nlm.nih.gov/pubmed/21857663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2106 |
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