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Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large-conductance voltage- and Ca(2+)-activated K(+) channel

Detrusor smooth muscle (DSM) exhibits increased spontaneous phasic contractions under pathophysiological conditions such as detrusor overactivity (DO). Our previous studies showed that activation of cAMP signaling pathways reduces DSM contractility by increasing the large-conductance voltage- and Ca...

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Главные авторы: Xin, Wenkuan, Cheng, Qiuping, Soder, Rupal P., Petkov, Georgi V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361951/
https://ncbi.nlm.nih.gov/pubmed/22322973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00432.2011
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