Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation

The large conductance voltage- and Ca(2+)-activated K(+) (BK) channel is a major regulator of detrusor smooth muscle (DSM) excitability and contractility. Recently, we showed that nonselective phosphodiesterase (PDE) inhibition reduces guinea pig DSM excitability and contractility by increasing BK c...

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Hlavní autoři: Xin, Wenkuan, Soder, Rupal P., Cheng, Qiuping, Rovner, Eric S., Petkov, Georgi V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492835/
https://ncbi.nlm.nih.gov/pubmed/22992675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00162.2012
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