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siRNA off-target effects in genome-wide screens identify signaling pathway members
We introduce a method for analyzing small interfering RNA (siRNA) genetic screens based entirely on off-target effects. Using a screen for members of the Wnt pathway, we demonstrate that this method identifies known pathway components, some of which are not present in the screening library. This tec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361704/ https://ncbi.nlm.nih.gov/pubmed/22645644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00428 |
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