MicroRNA-like off-target transcript regulation by siRNAs is species specific

siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match the guide-strand “seed region,” similar to the way microRNAs match their target sites. The extent to which this seed-matched, microRNA-like, of...

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Autori principali: Burchard, Julja, Jackson, Aimee L., Malkov, Vladislav, Needham, Rachel H.V., Tan, Yejun, Bartz, Steven R., Dai, Hongyue, Sachs, Alan B., Linsley, Peter S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648714/
https://ncbi.nlm.nih.gov/pubmed/19144911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1326809
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