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MicroRNA-like off-target transcript regulation by siRNAs is species specific
siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match the guide-strand “seed region,” similar to the way microRNAs match their target sites. The extent to which this seed-matched, microRNA-like, of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648714/ https://ncbi.nlm.nih.gov/pubmed/19144911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1326809 |
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