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A LIN28-dependent structural change of pre-let-7g directly inhibits Dicer processing

Several recent studies have provided evidence that LIN28, a cytoplasmic RNA-binding protein, inhibits the biogenesis of members of the let-7 microRNA (miRNA) family at the Dicer step in both mammals and C. elegans. However, the precise mechanism of inhibition is still poorly understood. Here we repo...

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Detalhes bibliográficos
Main Authors: Lightfoot, Helen L., Bugaut, Anthony, Armisen, Javier, Lehrbach, Nicolas J., Miska, Eric A., Balasubramanian, Shankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361669/
https://ncbi.nlm.nih.gov/pubmed/21815640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200851d
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