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A LIN28-dependent structural change of pre-let-7g directly inhibits Dicer processing
Several recent studies have provided evidence that LIN28, a cytoplasmic RNA-binding protein, inhibits the biogenesis of members of the let-7 microRNA (miRNA) family at the Dicer step in both mammals and C. elegans. However, the precise mechanism of inhibition is still poorly understood. Here we repo...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361669/ https://ncbi.nlm.nih.gov/pubmed/21815640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200851d |
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