LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

The let-7 microRNA (miRNA) is an ultraconserved regulator of stem cell differentiation and developmental timing, and a candidate tumour suppressor. Here we show that LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 processing in C. elegans. We demonstrate that lin-28 is necessary and sufficien...

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Bibliographic Details
Main Authors: Lehrbach, Nicolas J., Armisen, Javier, Lightfoot, Helen L., Murfitt, Kenneth J., Bugaut, Anthony, Balasubramanian, Shankar, Miska, Eric A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988485/
https://ncbi.nlm.nih.gov/pubmed/19713957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1675
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