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LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
The let-7 microRNA (miRNA) is an ultraconserved regulator of stem cell differentiation and developmental timing, and a candidate tumour suppressor. Here we show that LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 processing in C. elegans. We demonstrate that lin-28 is necessary and sufficien...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988485/ https://ncbi.nlm.nih.gov/pubmed/19713957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1675 |
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