LIN‐28 balances longevity and germline stem cell number in Caenorhabditis elegans through let‐7/AKT/DAF‐16 axis

The RNA‐binding protein LIN‐28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin‐28 enhanced stress tolerance and longevity, and reduced ge...

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Publicat a:Aging Cell
Autors principals: Wang, Dan, Hou, Lei, Nakamura, Shuhei, Su, Ming, Li, Fang, Chen, Weiyang, Yan, Yizhen, Green, Christopher D., Chen, Di, Zhang, Hong, Antebi, Adam, Han, Jing‐Dong J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242300/
https://ncbi.nlm.nih.gov/pubmed/27730721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12539
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