Improved stability of multivalent antibodies containing the human collagen XV trimerization domain

We recently described the in vitro and in vivo properties of an engineered homotrimeric antibody made by fusing the N-terminal trimerization region of collagen XVIII NC1 domain to the C-terminus of a scFv fragment [trimerbody (scFv-NC1)(3); 110 kDa]. Here, we demonstrated the utility of the N-termin...

Full description

Saved in:
Bibliographic Details
Main Authors: Cuesta, Ángel M, Sánchez-Martín, David, Blanco-Toribio, Ana, Villate, Maider, Enciso-Álvarez, Kelly, Alvarez-Cienfuegos, Ana, Sainz-Pastor, Noelia, Sanz, Laura, Blanco, Francisco J, Álvarez-Vallina, Luis
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361658/
https://ncbi.nlm.nih.gov/pubmed/22453098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.4.2.19140
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items