Increased Risk of Lung Cancer Associated with a Functionally Impaired Polymorphic Variant of the Human DNA Glycosylase NEIL2

Human NEIL2, one of five oxidized base-specific DNA glycosylases, is unique in preferentially repairing oxidative damage in transcribed genes. Here we show that depletion of NEIL2 causes a 6- to 7-fold increase in spontaneous mutation frequency in the HPRT gene of the V79 Chinese hamster lung cell l...

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Detalhes bibliográficos
Main Authors: Dey, Sanjib, Maiti, Amit K, Hegde, Muralidhar L, Hegde, Pavana M, Boldogh, Istvan, Sarkar, Partha S, Abdel-Rahman, Sherif Z, Sarker, Altaf H., Hang, Bo, Xie, Jingwu, Tomkinson, Alan E, Zhou, Mian, Shen, Binghui, Wang, Guanghai, Wu, Chen, Yu, Dianke, Lin, Dongxin, Cardenas, Victor, Hazra, Tapas K
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361577/
https://ncbi.nlm.nih.gov/pubmed/22497777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.03.005
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