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Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor
The dynamic character of G protein-coupled receptors is essential to their function. However, the details of how ligands stabilize a particular conformation to selectively activate a signaling pathway and how signaling proteins affect this conformational repertoire remain unclear. Using a prototypic...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361445/ https://ncbi.nlm.nih.gov/pubmed/22573814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119881109 |
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