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Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay
The tumor suppressor protein, p53, is either mutated or absent in >50% of cancers and is negatively regulated by the mouse double minute (MDM2) protein. Understanding and inhibition of the MDM2-p53 interaction are, therefore, critical for developing novel chemotherapeutics, which are currently li...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361394/ https://ncbi.nlm.nih.gov/pubmed/22556265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116637109 |
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