Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin‐3

Drugs targeting MDM2's hydrophobic pocket activate p53. However, these agents act allosterically and have agonist effects on MDM2's protein interaction landscape. Dominant p53‐independent MDM2‐drug responsive‐binding proteins have not been stratified. We used as a variable the differential...

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Detalhes bibliográficos
Publicado no:Proteomics
Main Authors: Way, Luke, Faktor, Jakub, Dvorakova, Petra, Nicholson, Judith, Vojtesek, Borek, Graham, Duncan, Ball, Kathryn L., Hupp, Ted
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026170/
https://ncbi.nlm.nih.gov/pubmed/27273042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201500501
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