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A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity
The MDM2 oncoprotein plays multiple regulatory roles in the control of p53-dependent gene expression. A picture of MDM2 is emerging where structurally discrete but interdependent functional domains are linked through changes in conformation. The domain structure includes: (i) a hydrophobic pocket at...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670157/ https://ncbi.nlm.nih.gov/pubmed/19188367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809294200 |
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