A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity

The MDM2 oncoprotein plays multiple regulatory roles in the control of p53-dependent gene expression. A picture of MDM2 is emerging where structurally discrete but interdependent functional domains are linked through changes in conformation. The domain structure includes: (i) a hydrophobic pocket at...

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Bibliografske podrobnosti
Main Authors: Wawrzynow, Bartosz, Pettersson, Susanne, Zylicz, Alicja, Bramham, Janice, Worrall, Erin, Hupp, Ted R., Ball, Kathryn L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Enzyme Catalysis and Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670157/
https://ncbi.nlm.nih.gov/pubmed/19188367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809294200
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