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Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay

The tumor suppressor protein, p53, is either mutated or absent in >50% of cancers and is negatively regulated by the mouse double minute (MDM2) protein. Understanding and inhibition of the MDM2-p53 interaction are, therefore, critical for developing novel chemotherapeutics, which are currently li...

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Detalhes bibliográficos
Main Authors: Robson, Anna F., Hupp, Ted R., Lickiss, Fiona, Ball, Kathryn L., Faulds, Karen, Graham, Duncan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361394/
https://ncbi.nlm.nih.gov/pubmed/22556265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116637109
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