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Gabapentin inhibits γ-Amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats
BACKGROUND: Gabapentin reduces acute postoperative and chronic neuropathic pain, but its sites and mechanisms of action are unclear. Based on previous electrophysiologic studies, we tested whether gabapentin reduced γ-Amino butyric acid (GABA) release in the locus coeruleus (LC), a major site of des...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360795/ https://ncbi.nlm.nih.gov/pubmed/22487864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318254e6fd |
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