Gabapentin Acts within the Locus Coeruleus to Alleviate Neuropathic Pain

BACKGROUND: Gabapentin recruits descending inhibition to produce analgesia after nerve injury, but whether this is a local action in the brainstem is unknown. The authors hypothesized that gabapentin activates noradrenergic neurons in the locus coeruleus (LC) by a local action. METHODS: Male rats un...

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Bibliografiske detaljer
Main Authors: Hayashida, Ken-ichiro, Obata, Hideaki, Nakajima, Kunie, Eisenach, James C.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843419/
https://ncbi.nlm.nih.gov/pubmed/19034104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31818dac9c
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