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Ondansetron reverses anti-hypersensitivity from clonidine in rats following peripheral nerve injury: Role of γ-amino butyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia

INTRODUCTION: Monoaminergic pathways, impinging an α2-adrenoceptors and 5-HT3 serotonin receptors, modulate nociceptive transmission, but their mechanisms and interactions after neuropathic injury are unknown. Here we examine these interactions in rodents after nerve injury. METHODS: Male Sprague-Da...

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Detalhes bibliográficos
Main Authors: Hayashida, Ken-ichiro, Kimura, Masafumi, Yoshizumi, Masaru, Hobo, Shotaro, Obata, Hideaki, Eisenach, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496934/
https://ncbi.nlm.nih.gov/pubmed/22722575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318260d381
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