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A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury
Spinally released brain derived nerve growth factor (BDNF) after nerve injury is essential to anatomic and functional changes in spinal noradrenergic and cholinergic systems which are engaged or targeted by commonly used treatments for neuropathic pain. Since BDNF signals via tropomyosine receptor k...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988873/ https://ncbi.nlm.nih.gov/pubmed/20638911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2010.05.005 |
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