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Asymmetric siRNA: New Strategy to Improve Specificity and Reduce Off-Target Gene Expression
Small interfering RNAs (siRNAs) have been used extensively in reverse genetic research, and many have made their way into clinical trials. The most widely used siRNA structure consists of double-stranded RNA with 19 base pairs and 2-nucleotide overhangs at the 3’-end of both strands (19+2). Although...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360511/ https://ncbi.nlm.nih.gov/pubmed/22229698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.145 |
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