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Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects
Argonaute (Ago) proteins form the core of RNA-induced silencing complexes (RISCs) and mediate small RNA-guided gene silencing. In RNAi, short interfering RNAs (siRNAs) guide RISCs to complementary target RNAs, leading to cleavage by the endonuclease Ago2. Noncatalytic Ago proteins, however, contribu...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062184/ https://ncbi.nlm.nih.gov/pubmed/21367974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2348111 |
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