ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y(2) receptors

Cardiac fibroblasts (CFs) play an essential role in remodeling of the cardiac extracellular matrix. Extracellular nucleotide signaling may provoke a profibrotic response in CFs. We tested the hypothesis that physical perturbations release ATP from CFs and that ATP participates in profibrotic signali...

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Autors principals: Lu, David, Soleymani, Sahar, Madakshire, Rohit, Insel, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2012
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360157/
https://ncbi.nlm.nih.gov/pubmed/22415310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-204677
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