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ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y(2) receptors

Cardiac fibroblasts (CFs) play an essential role in remodeling of the cardiac extracellular matrix. Extracellular nucleotide signaling may provoke a profibrotic response in CFs. We tested the hypothesis that physical perturbations release ATP from CFs and that ATP participates in profibrotic signali...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lu, David, Soleymani, Sahar, Madakshire, Rohit, Insel, Paul A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360157/
https://ncbi.nlm.nih.gov/pubmed/22415310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-204677
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