ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y(2) receptors

Cardiac fibroblasts (CFs) play an essential role in remodeling of the cardiac extracellular matrix. Extracellular nucleotide signaling may provoke a profibrotic response in CFs. We tested the hypothesis that physical perturbations release ATP from CFs and that ATP participates in profibrotic signali...

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Bibliografiska uppgifter
Huvudupphovsmän: Lu, David, Soleymani, Sahar, Madakshire, Rohit, Insel, Paul A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2012
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360157/
https://ncbi.nlm.nih.gov/pubmed/22415310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-204677
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