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ATP and glutamate released via astroglial connexin43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

Inflammation contributes to neurodegeneration in post-ischemic brain, diabetes, and Alzheimer’s disease. Participants to this inflammatory response include activation of microglia and astrocytes. We studied the role of microglia treated with amyloid-β peptide (Aβ) on hemichannel activity of astrocyt...

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Detalhes bibliográficos
Main Authors: Orellana, Juan A., Froger, Nicolas, Ezan, Pascal, Jiang, Jean X., Bennett, Michael V. L., Naus, Christian C., Giaume, Christian, Sáez, Juan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108012/
https://ncbi.nlm.nih.gov/pubmed/21294731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07210.x
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