Stratification of Wilms tumor by genetic and epigenetic analysis

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutat...

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Detalhes bibliográficos
Main Authors: Scott, Richard H., Murray, Anne, Baskcomb, Linda, Turnbull, Clare, Loveday, Chey, Al-Saadi, Reem, Williams, Richard, Breatnach, Fin, Gerrard, Mary, Hale, Juliet, Kohler, Janice, Lapunzina, Pablo, Levitt, Gill A., Picton, Sue, Pizer, Barry, Ronghe, Milind D., Traunecker, Heidi, Williams, Denise, Kelsey, Anna, Vujanic, Gordan M., Sebire, Neil J., Grundy, Paul, Stiller, Charles A., Pritchard-Jones, Kathy, Douglas, Jenny, Rahman, Nazneen
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359888/
https://ncbi.nlm.nih.gov/pubmed/22470196
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