Stratification of Wilms tumor by genetic and epigenetic analysis

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutat...

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Main Authors: Scott, Richard H., Murray, Anne, Baskcomb, Linda, Turnbull, Clare, Loveday, Chey, Al-Saadi, Reem, Williams, Richard, Breatnach, Fin, Gerrard, Mary, Hale, Juliet, Kohler, Janice, Lapunzina, Pablo, Levitt, Gill A., Picton, Sue, Pizer, Barry, Ronghe, Milind D., Traunecker, Heidi, Williams, Denise, Kelsey, Anna, Vujanic, Gordan M., Sebire, Neil J., Grundy, Paul, Stiller, Charles A., Pritchard-Jones, Kathy, Douglas, Jenny, Rahman, Nazneen
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2012
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359888/
https://ncbi.nlm.nih.gov/pubmed/22470196
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