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Sustained Activation of AMPK Ameliorates Age-Associated Vascular Endothelial Dysfunction via a Nitric Oxide-Independent Mechanism

Exercise restores endothelium-dependent dilation (EDD) in old mice by reducing oxidative stress and increasing nitric oxide (NO) bioavailability. Adenosine monophosphate protein kinase (AMPK) activation mimics some effects of exercise. Old (28–30 mo) B6D2F1 mice had reduced arterial AMPK expression...

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Main Authors: Lesniewski, Lisa A., Zigler, Melanie C, Durrant, Jessica R, Donato, Anthony J, Seals, Douglas R
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359767/
https://ncbi.nlm.nih.gov/pubmed/22484146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.03.011
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