Sustained Activation of AMPK Ameliorates Age-Associated Vascular Endothelial Dysfunction via a Nitric Oxide-Independent Mechanism

Exercise restores endothelium-dependent dilation (EDD) in old mice by reducing oxidative stress and increasing nitric oxide (NO) bioavailability. Adenosine monophosphate protein kinase (AMPK) activation mimics some effects of exercise. Old (28–30 mo) B6D2F1 mice had reduced arterial AMPK expression...

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Detalhes bibliográficos
Main Authors: Lesniewski, Lisa A., Zigler, Melanie C, Durrant, Jessica R, Donato, Anthony J, Seals, Douglas R
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359767/
https://ncbi.nlm.nih.gov/pubmed/22484146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.03.011
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