Analysis of the Paired TCR α- and β-chains of Single Human T Cells

Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses. Here we describe a multiplex RT-PCR based tec...

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Bibliographic Details
Main Authors: Kim, Song-Min, Bhonsle, Latika, Besgen, Petra, Nickel, Jens, Backes, Anna, Held, Kathrin, Vollmer, Sigrid, Dornmair, Klaus, Prinz, Joerg C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359365/
https://ncbi.nlm.nih.gov/pubmed/22649519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037338
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