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Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

The checkpoint kinases Chk1 and ATR are broadly known for their role in the response to the accumulation of damaged DNA. Because Chk1 activation requires its phosphorylation by ATR, it is expected that ATR or Chk1 down-regulation should cause similar alterations in the signals triggered by DNA lesio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Speroni, Juliana, Federico, María Belén, Mansilla, Sabrina F., Soria, Gastón, Gottifredi, Vanesa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358916/
https://ncbi.nlm.nih.gov/pubmed/22529391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116345109
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