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Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA
The checkpoint kinases Chk1 and ATR are broadly known for their role in the response to the accumulation of damaged DNA. Because Chk1 activation requires its phosphorylation by ATR, it is expected that ATR or Chk1 down-regulation should cause similar alterations in the signals triggered by DNA lesio...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358916/ https://ncbi.nlm.nih.gov/pubmed/22529391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116345109 |
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