UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, we show that forced p21 stabilization after UV strongly impairs damaged-DNA re...

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Detalles Bibliográficos
Autores principales: Mansilla, Sabrina F., Soria, Gastón, Vallerga, María Belén, Habif, Martín, Martínez-López, Wilner, Prives, Carol, Gottifredi, Vanesa
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737556/
https://ncbi.nlm.nih.gov/pubmed/23723248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt475
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