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UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability
Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, we show that forced p21 stabilization after UV strongly impairs damaged-DNA re...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737556/ https://ncbi.nlm.nih.gov/pubmed/23723248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt475 |
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