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Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin
Cisplatin (cis-diamminedichloroplatinum) and related compounds cause DNA damage and are widely used as anticancer agents. Chemoresistance to cisplatin treatment is due in part to translesion synthesis by human DNA polymerase η (hPol η). Here, we report crystal structures of hPol η complexed with int...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358888/ https://ncbi.nlm.nih.gov/pubmed/22529383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202681109 |
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