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Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn(2+) over Cd(2+) selectivity
Zinc and cadmium are similar metal ions, but though Zn(2+) is an essential nutrient, Cd(2+) is a toxic and common pollutant linked to multiple disorders. Faster body turnover and ubiquitous distribution of Zn(2+) vs. Cd(2+) suggest that a mammalian metal transporter distinguishes between these metal...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358884/ https://ncbi.nlm.nih.gov/pubmed/22529353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200362109 |
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