Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn(2+) is driven by an active Ca(2+)-coupled exchange

Manganese (Mn(2+)) is extruded from the cell by the zinc transporter 10 (ZnT10). Loss of ZnT10 expression caused by autosomal mutations in the ZnT10 gene leads to hypermanganesemia in multiple organs. Here, combining fluorescent monitoring of cation influx in HEK293-T cells expressing human ZnT10 wi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Levy, Moshe, Elkoshi, Nadav, Barber-Zucker, Shiran, Hoch, Eitan, Zarivach, Raz, Hershfinkel, Michal, Sekler, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463715/
https://ncbi.nlm.nih.gov/pubmed/30755481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006816
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