Metabolism and Distribution of Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in Human Lung Cells by Liquid Chromatography Tandem Mass Spectrometry: Detection of an Adenine B[a]P-7,8-dione Adduct

Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) is produced in human lung cells by the oxidation of (±)-B[a]P-7,8-trans-dihydrodiol, which is catalyzed by aldo-keto reductases (AKRs). However, information relevant to the cell-based metabolism of B[a]P-7,8-dione is lacking. We studied the metabolic fate o...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Huang, Meng, Liu, Xiaojing, Basu, Sankha S., Zhang, Li, Kushman, Mary E., Harvey, Ronald G., Blair, Ian A., Penning, Trevor M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358497/
https://ncbi.nlm.nih.gov/pubmed/22480306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200463s
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