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Interception of Benzo[a]pyrene-7,8-dione by UDP Glucuronosyltransferases (UGTs) in Human Lung Cells

[Image: see text] Polycyclic aromatic hydrocarbons (PAHs) are environmental and tobacco carcinogens. Proximate carcinogenic PAH trans-dihydrodiols are activated by human aldo-keto reductases (AKRs) to yield electrophilic and redox-active o-quinones. Interconversion among benzo[a]pyrene (B[a]P)-7,8-d...

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Detalhes bibliográficos
Main Authors: Zhang, Li, Huang, Meng, Blair, Ian A., Penning, Trevor M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829198/
https://ncbi.nlm.nih.gov/pubmed/24047243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400268q
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