Detoxication of Benzo[a]pyrene-7,8-dione by Sulfotransferases (SULTs) in Human Lung Cells

Polycyclic aromatic hydrocarbons (PAH) are environmental and tobacco carcinogens. Human aldo-keto reductases catalyze the metabolic activation of proximate carcinogenic PAH trans-dihydrodiols to yield electrophilic and redox-active o-quinones. Benzo[a]pyrene-7,8-dione a representative PAH o-quinone...

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Bibliographic Details
Main Authors: Zhang, Li, Huang, Meng, Blair, Ian A., Penning, Trevor M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436139/
https://ncbi.nlm.nih.gov/pubmed/22782890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386052
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