Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain

Genome-wide association studies have nominated many genetic variants for common human traits, including diseases, but in many cases the underlying biological reason for a trait association is unknown. Subsets of genetic polymorphisms show a statistical association with transcript expression levels,...

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Autors principals: Hernandez, Dena G., Nalls, Mike A., Moore, Matthew, Chong, Sean, Dillman, Allissa, Trabzuni, Daniah, Gibbs, J. Raphael, Ryten, Mina, Arepalli, Sampath, Weale, Michael E., Zonderman, Alan B., Troncoso, Juan, O'Brien, Richard, Walker, Robert, Smith, Colin, Bandinelli, Stefania, Traynor, Bryan J., Hardy, John, Singleton, Andrew B., Cookson, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358430/
https://ncbi.nlm.nih.gov/pubmed/22433082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.03.020
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