Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies

Polymorphisms in the target mRNA sequence can greatly affect the binding affinity of microarray probe sequences, leading to false-positive and false-negative expression quantitative trait locus (QTL) signals with any other polymorphisms in linkage disequilibrium. We provide the most complete solutio...

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Hauptverfasser: Ramasamy, Adaikalavan, Trabzuni, Daniah, Gibbs, J. Raphael, Dillman, Allissa, Hernandez, Dena G., Arepalli, Sampath, Walker, Robert, Smith, Colin, Ilori, Gigaloluwa Peter, Shabalin, Andrey A., Li, Yun, Singleton, Andrew B., Cookson, Mark R., Hardy, John, Ryten, Mina, Weale, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627570/
https://ncbi.nlm.nih.gov/pubmed/23435227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt069
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