Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain

Genome-wide association studies have nominated many genetic variants for common human traits, including diseases, but in many cases the underlying biological reason for a trait association is unknown. Subsets of genetic polymorphisms show a statistical association with transcript expression levels,...

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Auteurs principaux: Hernandez, Dena G., Nalls, Mike A., Moore, Matthew, Chong, Sean, Dillman, Allissa, Trabzuni, Daniah, Gibbs, J. Raphael, Ryten, Mina, Arepalli, Sampath, Weale, Michael E., Zonderman, Alan B., Troncoso, Juan, O'Brien, Richard, Walker, Robert, Smith, Colin, Bandinelli, Stefania, Traynor, Bryan J., Hardy, John, Singleton, Andrew B., Cookson, Mark R.
Format: Artigo
Langue:Inglês
Publié: Academic Press 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358430/
https://ncbi.nlm.nih.gov/pubmed/22433082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.03.020
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