Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors. We also show that genetically altering STAT3 at Lys685 reduces tumor growth, whic...

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Bibliografski detalji
Glavni autori: Lee, Heehyoung, Zhang, Peng, Herrmann, Andreas, Yang, Chunmei, Xin, Hong, Wang, Zhenghe, Hoon, Dave S. B., Forman, Stephen J., Jove, Richard, Riggs, Arthur D., Yu, Hua
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356652/
https://ncbi.nlm.nih.gov/pubmed/22547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205132109
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