Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors. We also show that genetically altering STAT3 at Lys685 reduces tumor growth, whic...

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Bibliografiske detaljer
Main Authors: Lee, Heehyoung, Zhang, Peng, Herrmann, Andreas, Yang, Chunmei, Xin, Hong, Wang, Zhenghe, Hoon, Dave S. B., Forman, Stephen J., Jove, Richard, Riggs, Arthur D., Yu, Hua
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356652/
https://ncbi.nlm.nih.gov/pubmed/22547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205132109
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