Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors. We also show that genetically altering STAT3 at Lys685 reduces tumor growth, whic...

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Hauptverfasser: Lee, Heehyoung, Zhang, Peng, Herrmann, Andreas, Yang, Chunmei, Xin, Hong, Wang, Zhenghe, Hoon, Dave S. B., Forman, Stephen J., Jove, Richard, Riggs, Arthur D., Yu, Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356652/
https://ncbi.nlm.nih.gov/pubmed/22547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205132109
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